Joint association of urinary albumin-to-creatinine ratio within normal range and triglyceride-glucose index with incident cardiovascular disease: a prospective cohort study
The study demonstrates that both elevated UACR (within normal range) and higher TyG index are jointly associated with increased CVD risk, with evidence suggesting potential bidirectional mediation. Their combined assessment provides significant incremental predictive value, supporting its integration into high-risk population screening for precise CVD prevention and management.
Authors
- Jianwei Xu (ORCID: https://orcid.org/0000-0003-0044-4309)
- Jing Dong (ORCID: https://orcid.org/0000-0002-7027-9567)
- Gao Congcong
- Jing Wu (ORCID: https://orcid.org/0000-0002-4061-8185)
- Xu Chunxiao
- Xiaorong Chen (ORCID: https://orcid.org/0000-0003-0185-0624)
- Jie Ren (ORCID: https://orcid.org/0000-0002-4595-3281)
- Xiaolei Guo (ORCID: https://orcid.org/0000-0003-0047-4479)
- Junli Tang (ORCID: https://orcid.org/0009-0009-0040-1617)
- Jixiang Ma (ORCID: https://orcid.org/0000-0002-9649-0088)
- Zilong Lu (ORCID: https://orcid.org/0000-0003-4977-7243)
- Zhang Ji-yu
- Du Fengjun
- Zhang Binyin
Institutions
- Shandong University (CN)
- National Center for Chronic and Noncommunicable Disease Control and Prevention (CN)
- Shandong Provincial Hospital (CN)
- Shandong Center for Disease Control and Prevention (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1186/s12933-025-03009-8
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chinese Center for Disease Control and Prevention