Malaria Screening and Treatment in Hematopoietic Cell Transplant Donors and Sickle Cell Disease Candidates/Recipients: A Case Series Using Malaria Polymerase Chain Reaction Testing and a Literature Review
Asymptomatic HCT donors and candidates with potential exposure to malaria should undergo screening. Malaria PCR offers greater diagnostic sensitivity than conventional methods. PCR utilization may prevent unnecessary donor deferrals and avoided empiric malaria treatment. Moreover, PCR negativity post-treatment may help confirm donor and candidate eligibility. These observations warrant validation in larger studies.
Authors
- Emily Limerick (ORCID: https://orcid.org/0000-0003-1591-2451)
- Jennifer Cuellar‐Rodríguez (ORCID: https://orcid.org/0000-0001-5298-6463)
- Matthew M. Hsieh (ORCID: https://orcid.org/0000-0002-3706-6615)
- Mary M. Czech (ORCID: https://orcid.org/0000-0002-8986-5419)
- Courtney D. Fitzhugh (ORCID: https://orcid.org/0000-0002-5306-7167)
- Sanchita Das (ORCID: https://orcid.org/0009-0008-1369-5688)
Institutions
- National Institutes of Health (US)
- National Heart, Lung, and Blood Institute (US)
- National Institute of Allergy and Infectious Diseases (US)
Publication Details
- Journal
- Transplant Infectious Disease
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1111/tid.70139
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases
- National Institutes of Health
- National Heart, Lung, and Blood Institute
- National Institute of Allergy and Infectious Diseases
- NIH Clinical Center
- NHLBI Division of Intramural Research