Relationship between efficacy and preferential targeting of soluble Aβ aggregates
Selectivity for toxic Aβ oligomers has potential to maximize efficacy and safety.Avoidance of Aβ monomers increases binding to toxic AD brain oligomers.Avoidance of Aβ plaque/vascular deposits reduces the risk of ARIA.
Authors
- Ebrima Gibbs (ORCID: https://orcid.org/0000-0002-6383-9239)
- Juliane Coutts
- Steven S. Plotkin (ORCID: https://orcid.org/0000-0001-8998-877X)
- Johanne Kaplan
- Ian R. Mackenzie (ORCID: https://orcid.org/0000-0003-3875-2972)
- Neil R. Cashman (ORCID: https://orcid.org/0000-0002-0080-1006)
- Beibei Zhao (ORCID: https://orcid.org/0000-0002-4445-8967)
Institutions
- Vancouver Coastal Health (CA)
- University of British Columbia (CA)
- Genome British Columbia (CA)
- Amorfix (Canada) (CA)
Publication Details
- Journal
- Alzheimer s & Dementia Translational Research & Clinical Interventions
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/trc2.70184
- Citations
- 1
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Fondation Brain Canada
- Canadian Institutes of Health Research