Effects of Biperiden (Cholinergic Muscarinic m1/m4 Receptor Antagonist) on Craving Nicotine: A Proof-Of-Concept Clinical Study
These findings suggest that biperiden may represent a promising pharmacological approach for reducing nicotine craving. Further studies with prolonged administration are warranted to evaluate its therapeutic potential for smoking cessation. .
Authors
- José Carlos Fernandes Galduróz (ORCID: https://orcid.org/0000-0002-2710-9693)
- José R. Jardim
- Rosângela Vicente
- Paola Palombo (ORCID: https://orcid.org/0000-0001-9721-2867)
- Shirley Takahashi
- Andréia Gomes Bezerra (ORCID: https://orcid.org/0000-0001-5534-6138)
- Giovanna Lira Rosa Ciutti
Institutions
- Fundação de Apoio à Universidade Federal de São Paulo (BR)
- Associação Paulista de Medicina (BR)
- Universidade Federal de São Paulo (BR)
Publication Details
- Journal
- European Addiction Research
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1159/000549810
- Primary Topic
- Nicotinic Acetylcholine Receptors Study
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Associação Fundo de Incentivo à Pesquisa