Sida Rhombifolia linn: an empirical analysis on phytochemicals and an in vitro outcome on anti-inflammatory and antioxidant perspective

Sida Rhombifolia Linn (SR) is a drug of importance in Ayurveda, used for the multiple disease therapy. In Ayurvedic Pharmacopeia, it is purported as source of Bala in India. It is reported as a rejuvenator of muscles with therapeutic effects in joint pains, rheumatism and neurological deficits. The study objective was to strengthen the chemosystemics and pharmacology of the genera via detailed phytochemical evaluation and invitro assessment of anti-inflammatory and cytotoxic properties. Preliminary analysis demonstrated presence of compounds like alkaloids, phenolics, flavonoids, etc. The invitro assessment revealed anti-inflammatory effect in real time PCR through gene panel expression of PERK, GRP78, ATF6, IRE1A and CHOP. The cell viability was tuned to concentrations up to 120 µg/ml. Through the phytochemical evaluation studies, the ubiquity of bioactive secondary metabolites with therapeutic functions were confirmed. This propagates the potential to feature as a primary constituent in drug development after further research.