Waldenström’s macroglobulinemia: The LYSA pragmatic guidelines
Waldenström's macroglobulinemia (WM) is a rare, indolent B-cell lymphoma that predominantly affects older adults. In recent years, significant progress has been made in understanding its pathogenesis, identifying relevant biomarkers, and developing novel therapeutic approaches to complement traditional chemoimmunotherapy-collectively reshaping the management landscape of WM. In this article, we provide comprehensive, evidence-based recommendations for the diagnosis, molecular evaluation, and treatment of WM, including strategies for both frontline and relapsed disease. These guidelines are informed by the latest clinical research, expert consensus, and current practice standards, with the goal of equipping clinicians with a practical and effective framework for delivering optimal care to patients with WM.
Authors
- Stéphanie Poulain (ORCID: https://orcid.org/0000-0002-1792-7270)
- Kamel Laribi (ORCID: https://orcid.org/0000-0002-4389-6164)
- Bénédicte Hivert (ORCID: https://orcid.org/0009-0007-2954-6743)
- Florence Nguyen‐Khac (ORCID: https://orcid.org/0000-0003-3107-6668)
- Cécile Tomowiak (ORCID: https://orcid.org/0000-0003-4093-6463)
- Marine Armand (ORCID: https://orcid.org/0000-0001-8906-3128)
- Éric Durot (ORCID: https://orcid.org/0000-0003-3463-0089)
- Stéphane Leprêtre (ORCID: https://orcid.org/0000-0003-4282-2160)
- Florian Bouclet (ORCID: https://orcid.org/0000-0003-0821-9536)
- David Ghez
- Pierre Morel (ORCID: https://orcid.org/0000-0002-0782-3144)
- Olivier Tournilhac (ORCID: https://orcid.org/0000-0002-9438-621X)
- Thérèse Aurran
- Damien Roos‐Weil (ORCID: https://orcid.org/0000-0002-7767-755X)
- Laurence Simon (ORCID: https://orcid.org/0000-0002-0451-2471)
- Lydia Montes (ORCID: https://orcid.org/0000-0003-3854-4209)
- Véronique Leblond
- Amine Moslemi
- Magali Le Garff Tavernier
Institutions
- Délégation Paris 5 (FR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Université de Lille (FR)
- Institut Gustave Roussy (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Sorbonne Université (FR)
- Sorbonne Paris Cité (FR)
- Centre de Recherche des Cordeliers (FR)
- Centre Hospitalier Universitaire Amiens-Picardie (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Centre Hospitalier Universitaire de Reims (FR)
- Centre Hospitalier Universitaire de Poitiers (FR)
- Centre Hospitalier Sud Francilien (FR)
- Pitié-Salpêtrière Hospital (FR)
- Centre Hospitalier du Mans (FR)
- Centre Hospitalier Universitaire de Clermont-Ferrand (FR)
- Groupe Hospitalier de l'Institut Catholique de Lille (FR)
- Laboratoire National Henri Becquerel (FR)
- Institut Paoli-Calmettes (FR)
- Université de Reims Champagne-Ardenne (FR)
Publication Details
- Journal
- European Journal of Cancer
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1016/j.ejca.2025.116120
- Citations
- 1
- Primary Topic
- Chronic Lymphocytic Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 1.63