Ginsenoside Rg5 mitigates tenocyte death via SIRT6/autophagy-dependent signaling in an aging model
These results suggest that Rg5 attenuates ER stress and oxidative stress through the SIRT6/autophagy axis, thereby mitigating ferroptosis and apoptosis in aging-conditioned tenocytes. The present study sheds light on a novel therapeutic strategy for aging-mediated tendinopathy involving the use of Rg5.
Authors
- Soon Auck Hong (ORCID: https://orcid.org/0000-0002-7902-4608)
- Tae Woo Jung (ORCID: https://orcid.org/0000-0002-1167-1892)
- Jun Hwi Ko
- Jong Wook Shin (ORCID: https://orcid.org/0000-0002-3988-1680)
- A.M. Abd El‐Aty (ORCID: https://orcid.org/0000-0001-6596-7907)
- Sung Ho Ahn (ORCID: https://orcid.org/0000-0002-8477-1026)
- Do Su Lim
- Hyeon Ji Gwon
- Wonjun Cho (ORCID: https://orcid.org/0000-0003-3554-3059)
- Ji Hoon Jeong
- Min Kyung Pyo
Institutions
- Cairo University (EG)
- Yonsei University (KR)
- Gangnam Severance Hospital (KR)
- Atatürk University (TR)
- Chung-Ang University (KR)
Publication Details
- Journal
- Journal of Ginseng Research
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1016/j.jgr.2025.11.009
- Primary Topic
- Tendon Structure and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00