Qingyu formula inhibits ferroptosis in HK-2 cells and in a diabetic nephropathy mouse model via the Nrf2/SLC7A11/GPX4 pathway
Qingyu formula protects against high glucose-induced renal injury by suppressing ferroptosis via the activation of the Nrf2/SLC7A11/GPX4 pathway. These findings support QYF as a promising candidate for targeting ferroptosis in DKD. Future studies should identify its active constituents and evaluate its efficacy in clinical trials.
Authors
- Jie Liu (ORCID: https://orcid.org/0000-0001-5310-7520)
- Tian Gao (ORCID: https://orcid.org/0000-0002-2485-5439)
- Yuanyuan Xu (ORCID: https://orcid.org/0000-0001-8335-5867)
Institutions
- Liuzhou Maternal and Child Health Hospital (CN)
- Liuzhou General Hospital (CN)
- Hangzhou Hospital of Traditional Chinese Medicine (CN)
- Jiangsu Province Hospital (CN)
Publication Details
- Journal
- Tissue and Cell
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1016/j.tice.2025.103236
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00