Fragmentation patterns of pathogen-derived cell-free DNA as a promising non-invasive biomarker for bloodstream infection diagnosis
Our findings demonstrate that pathogen-derived cfDNA exhibits distinct fragmentation patterns, providing a potential non-invasive tool to complement traditional diagnostic methods, particularly for hard-to-culture pathogens. However, further studies with larger sample sizes are needed to refine pathogen-specific fragment length ranges and validate its clinical applicability.
Authors
- Qian Fu (ORCID: https://orcid.org/0000-0002-7126-2994)
- Tianyu Lu (ORCID: https://orcid.org/0000-0002-7958-1594)
- Liya Yue (ORCID: https://orcid.org/0000-0002-5752-6914)
- Xiaoyuan Jiang
- Cuidan Li (ORCID: https://orcid.org/0000-0002-8430-1155)
- Wenyu Shi (ORCID: https://orcid.org/0000-0001-7036-8917)
- Fei Chen (ORCID: https://orcid.org/0000-0003-3895-6318)
- Jie Wang (ORCID: https://orcid.org/0000-0003-4635-2362)
- Peihan Wang (ORCID: https://orcid.org/0000-0001-6701-6179)
Institutions
- Chinese Academy of Sciences (CN)
- Beijing Institute of Genomics (CN)
- Xinjiang Uygur Autonomous Region Disease Prevention and Control Center (CN)
- Keio University Shonan Fujisawa (JP)
- University of Chinese Academy of Sciences (CN)
- China Agricultural University (CN)
Publication Details
- Journal
- Practical Laboratory Medicine
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1016/j.plabm.2025.e00513
- Citations
- 1
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.94