Whole-genome profiling of age- and sex-associated DNA methylation signatures in human plasma cell-free DNA
Our discovered CpGs and genes help to explain age-related and sex-biased diseases such as psychiatric disorders, diabetes, and autoimmune diseases, and we demonstrate the potential of cfDNA methylation signatures as very promising biomarkers for health monitoring for the general population.
Authors
- Chuang Xu (ORCID: https://orcid.org/0000-0002-0377-1439)
- Changlin Yang (ORCID: https://orcid.org/0000-0001-5687-600X)
- Yu Lin
- Jianhua Yin (ORCID: https://orcid.org/0000-0003-1207-7788)
- Qiuyan Li (ORCID: https://orcid.org/0000-0003-0852-3124)
- Haiqiang Zhang (ORCID: https://orcid.org/0000-0001-8757-4549)
- Wenbo Pang (ORCID: https://orcid.org/0000-0002-6685-3730)
- Xin Jin (ORCID: https://orcid.org/0000-0001-7554-4975)
- Wei Chen (ORCID: https://orcid.org/0000-0002-8087-7077)
- Xinxin Wang (ORCID: https://orcid.org/0000-0001-8238-7832)
- Yan Zhang (ORCID: https://orcid.org/0000-0003-2281-7807)
- Jinjin Xu (ORCID: https://orcid.org/0000-0002-9398-252X)
- Wenwen Zhou (ORCID: https://orcid.org/0000-0002-0646-6157)
- Yeqin Wang (ORCID: https://orcid.org/0000-0002-3841-2129)
- Rijing Ou
- Chenhui Zhao
- Guodan Zeng (ORCID: https://orcid.org/0000-0001-5438-0932)
Institutions
- BGI Group (China) (CN)
- Shanxi Medical University (CN)
- University of Chinese Academy of Sciences (CN)
- BGI Research (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1038/s43856-025-01220-y
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- General Hospital of People’s Liberation Army