Tibetan herbal medicine Oxytropis falcata Bunge ameliorates hypoxic pulmonary hypertension in rats via regulation of intestinal microbiota and metabolites
These findings suggest that OFB exerts therapeutic effects against HPH by modulating gut microbiota dysbiosis and restoring metabolic homeostasis, particularly within pyrimidine metabolism. The observed gut-lung axis interactions may underlie these effects, offering novel mechanistic insights and supporting the potential clinical development of OFB as a microbiota-targeted therapy for HPH.
Authors
- Xuefeng Cao (ORCID: https://orcid.org/0000-0002-4083-1533)
- Tian Luo
- Zhaoze Guo (ORCID: https://orcid.org/0000-0001-8847-7740)
- Xia Zhu (ORCID: https://orcid.org/0000-0003-1399-6620)
- Lan Ma (ORCID: https://orcid.org/0000-0001-9034-5472)
- Yuxin He (ORCID: https://orcid.org/0000-0002-0607-8744)
- Zhenzhong Bai (ORCID: https://orcid.org/0000-0003-4213-3605)
- Hua Xue
Institutions
- Qinghai University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-11-28
- DOI
- https://doi.org/10.3389/fmicb.2025.1538260
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00