Interfacing Thin‐Film Bioelectronics with Bone Regenerative Cryogel Scaffolds for Transosseous Cortical Access

ABSTRACT The integration of thin‐film bioelectronics with bone regenerative cryogel scaffolds offers a promising opportunity to directly interface electronics with the brain for long‐term recording through the skull. This study investigates the feasibility of combining thin‐film devices with a bone‐regenerative cryogel scaffold to promote closure of cranial windows for chronic neural recordings. In this study, a bioelectronic recording array is fabricated and integrated within a cryogel, and the combined system is evaluated in vivo for both bone regrowth and electrophysiological stability Microcomputed tomography (microCT) and histological analysis demonstrated comparable bone formation between cryogel‐only and device‐integrated scaffolds, with early mineral deposition and new bone development occurring throughout the defect. Notably, the implant system maintained stable electrophysiological signal acquisition both at the time of surgery and long term in freely moving animals. These findings demonstrate the feasibility of bioelectronic devices that integrate directly with bone‐regenerative scaffolds, supporting future applications in long‐term clinical neural interfacing and bioelectronic monitoring within bone‐rich anatomical sites.