Oviductus Ranae alleviates D-galactose-induced ovarian aging by inhibiting ferroptosis and regulating the GPX4/ACSL4 pathway
OR resists ovarian damage and prevents aging through antiferroptosis mechanisms by regulating the GPX4/ACSL4 axis in OGCs and aging rats. These results highlight the potential of OR as a therapeutic agent for the prevention and treatment of ovarian aging.
Authors
- Xinxin Zeng
- Lei Liang (ORCID: https://orcid.org/0000-0003-3294-2978)
- Zhen Zhang (ORCID: https://orcid.org/0000-0001-6753-2288)
- Xiaomei Ling (ORCID: https://orcid.org/0000-0002-0195-387X)
- Li‐Yue Sun (ORCID: https://orcid.org/0000-0003-1919-0820)
- Shun Liu (ORCID: https://orcid.org/0000-0002-1766-2057)
- Xuhui Zhang (ORCID: https://orcid.org/0009-0007-2418-2872)
- Jie Li (ORCID: https://orcid.org/0000-0002-6175-3167)
- Ming Li (ORCID: https://orcid.org/0000-0002-4824-8510)
- Cong Xie (ORCID: https://orcid.org/0000-0001-7269-0678)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Jinan University (CN)
- Fudan University (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Zhongshan Hospital (CN)
- Guangdong Provincial People's Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Ovarian Research
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1186/s13048-025-01857-2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00