Finally putting the horse before the cart?

The provocative review by Richie et al. (this issue) provides a platform for reflection on developing new experimental designs and data analysis methods. Here I offer support for their ideas, and add some additional considerations related to: (1) environmental image statistics, (2) multisensory experimentation, (3) embracing non-linearities in brain-body function and tackling data with non-linear analysis approaches; (4) perturbing mature cortical networks with Focused Ultrasound (FUS) or Transcranial Magnetic Stimulation (TMS) guided by functional magnetic resonance imaging (fMRI) activation; and (5) considering spatial scales and aberrant scaffolding in human development.