A post-implementation evaluation of BioFire FilmArray Meningitis/Encephalitis panel for pathogen detection in cerebrospinal fluid with a special focus on clinical significance of HHV-6

Utilization of molecular testing methods enables rapid and high-sensitivity diagnostics, which can have significant impacts upon clinical outcomes in meningitis and encephalitis. However, challenges remain with the interpretation of results when syndromic panels are used, such as with the detection of human herpesvirus 6 (HHV-6) in cerebrospinal fluid (CSF). This study aimed to evaluate the BioMerieux BioFire FilmArray Meningitis/Encephalitis panel for the detection of pathogens in CSF in an adult and pediatric population. Data demonstrated that performing CSF nucleic acid amplification testing without diagnostic stewardship strategies in place can be associated with increased detection of potential bystander pathogens, including HHV-6.