Autologous platelet concentrate augmentation in anterior cruciate ligament reconstruction: a level I evidence-based meta-analysis
The current level of I evidence does not support APC augmentation as a means to improve short-term outcomes or reduce complications after ACL reconstruction; however, its safety profile and biological rationale justify further high-quality RCTs with standardized protocols and longer follow-up.
Authors
- Filippo Migliorini (ORCID: https://orcid.org/0000-0001-7220-1221)
- Naveen Jeyaraman (ORCID: https://orcid.org/0000-0002-4362-3326)
- Ludovico Lucenti (ORCID: https://orcid.org/0000-0002-9514-9304)
- Madhan Jeyaraman (ORCID: https://orcid.org/0000-0002-9045-9493)
- Gennaro Pipino (ORCID: https://orcid.org/0000-0002-1096-8467)
- Luise Schäfer (ORCID: https://orcid.org/0009-0005-2047-4515)
- Francesco Simeone
Institutions
- Dr. M.G.R. Educational and Research Institute (IN)
- ACS Medical College and Hospital (IN)
- Institute for Stem Cell Biology and Regenerative Medicine (IN)
- Ospedale di Bolzano (IT)
- Orthopaedic Trauma Association (US)
- Regenerative Medicine Institute (MX)
- University Hospital in Halle (DE)
- Villa Torri Hospital (IT)
- Link Campus University (IT)
- Martin Luther University Halle-Wittenberg (DE)
- University of Palermo (IT)
Publication Details
- Journal
- Die Orthopädie
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1007/s00132-025-04748-y
- Primary Topic
- Knee injuries and reconstruction techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00