Macrophage Paracrine Signalling Differentially Affects Fibroblast-Induced Collagenous Tissue Remodelling
Factors secreted by M1 macrophages resulted in reduced tissue compaction compared to M2a/M2c macrophages in an in vitro model of tissue remodelling, suggesting a diminished capacity for fibroblasts to remodel the extracellular matrix. Importantly, factors to polarize macrophages and serum are regarded as confounding factors in studying the effect of paracrine signalling by macrophages on tissue remodelling.
Authors
- Amal Mansoor
- Jasper Foolen (ORCID: https://orcid.org/0000-0002-1065-7423)
- Carlijn V. C. Bouten (ORCID: https://orcid.org/0000-0003-1035-5094)
- Anthal I.P.M. Smits (ORCID: https://orcid.org/0000-0002-3665-7106)
- Hannah F. M. Brouwer (ORCID: https://orcid.org/0000-0003-3745-8894)
- Keita Ito (ORCID: https://orcid.org/0000-0002-7372-4072)
- Sylvia Dekker
Institutions
- Eindhoven University of Technology (NL)
Publication Details
- Journal
- Tissue Engineering and Regenerative Medicine
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1007/s13770-025-00766-1
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission