The N-butanol extract of modified Yanghe decoction alleviates ferroptosis in bone marrow mesenchymal stem cells in glucocorticoid-induced osteoporosis by activating the HIF-1α/GPX4 signaling pathway
MYHD-NB mitigates ferroptosis triggered by DEX in BMSCs while enhancing osteogenic differentiation via the HIF-1α/GPX4 signaling pathway, elucidating its therapeutic mechanism against GIOP. These results demonstrate MYHD-NB's superior osteogenic potential within the MYHD formulation, positioning it as a promising candidate for alternative GIOP management strategies.
Authors
- Jiangyuan Liu (ORCID: https://orcid.org/0000-0001-5808-9974)
- Wenlong Yang (ORCID: https://orcid.org/0000-0001-5556-2068)
- Fan Wu (ORCID: https://orcid.org/0000-0003-1845-437X)
- Hanting Xia
- Duanguang Cao (ORCID: https://orcid.org/0000-0002-3529-1093)
- Fengyun Yang (ORCID: https://orcid.org/0009-0002-2644-7129)
Institutions
- Jiangxi University of Traditional Chinese Medicine (CN)
- Zhejiang Chinese Medical University (CN)
- Zhejiang Hospital (CN)
- Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1186/s13018-025-06404-9
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52