Exosomes derived from menstrual blood-derived mesenchymal stem cells and treadmill training restore motor function following SCI by activating PI3K/Akt pathway
MenSCs-Exo combined with WSTT synergistically enhances motor recovery after SCI by promoting tissue repair, reducing fibrosis, and activating the PI3K/Akt pathway. This cell-free therapy paired with rehabilitation exercise offers a novel strategy for SCI treatment.
Authors
- Chuanming Dong (ORCID: https://orcid.org/0000-0002-5835-5950)
- Muxing Li (ORCID: https://orcid.org/0000-0002-1827-5155)
- Yujing Shi (ORCID: https://orcid.org/0000-0002-4221-6665)
- Hui Song (ORCID: https://orcid.org/0000-0003-4415-3431)
- Yuyu Sun (ORCID: https://orcid.org/0000-0002-1614-6368)
- Longju Qi (ORCID: https://orcid.org/0000-0002-0128-4848)
- Shiyuan Chen (ORCID: https://orcid.org/0000-0001-9805-2906)
- Qinghua Wang (ORCID: https://orcid.org/0000-0003-3912-3174)
- Wenqi Wang (ORCID: https://orcid.org/0000-0003-4053-5088)
- Jinyi Liu (ORCID: https://orcid.org/0000-0003-1803-7752)
- Liya Zhang (ORCID: https://orcid.org/0000-0002-8974-5142)
- Jiaxi Chen (ORCID: https://orcid.org/0000-0002-6458-6464)
- Jiaqi Dai (ORCID: https://orcid.org/0000-0002-6457-5415)
- Wenwei Jiang
- Yuan-xu Pu
Institutions
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
- Second People's Hospital of NanTong (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1186/s13287-025-04794-5
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jiangsu Commission of Health
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province
- Nantong University
- Science and Technology Project of Nantong City