Pathological complete response to pembrolizumab in recurrent retroperitoneal dedifferentiated liposarcoma with high tumor mutational burden: a case report
This is the first reported case of recurrent retroperitoneal DDLPS with high TMB achieving pCR to pembrolizumab. High TMB and high TAM density in the tumor microenvironment may be predictive biomarkers for the response to ICIs in DDLPS.
Authors
- Yusuke Kawachi (ORCID: https://orcid.org/0009-0006-8676-9049)
- Kohei Miura (ORCID: https://orcid.org/0000-0001-9874-1795)
- Takashi Kobayashi (ORCID: https://orcid.org/0000-0003-1069-2816)
- Kazuyasu Takizawa (ORCID: https://orcid.org/0000-0002-0422-5456)
- Shun Abe
- Hiroyuki Kawashima (ORCID: https://orcid.org/0000-0001-9511-9773)
- Toshifumi Wakai (ORCID: https://orcid.org/0000-0003-2443-3428)
- Jun Sakata
- Mika Sugai
- Yuki Hirose (ORCID: https://orcid.org/0000-0001-6879-7886)
- Takashi Ariizumi (ORCID: https://orcid.org/0000-0002-0777-1612)
- Hiroshi Ichikawa (ORCID: https://orcid.org/0000-0002-6515-5316)
- Qiliang Zhou (ORCID: https://orcid.org/0000-0002-3530-8756)
- Takuya Ando
- Yoshifumi Shimada
- Hirosuke Ishikawa (ORCID: https://orcid.org/0000-0001-6150-3857)
Institutions
- Niigata University Medical and Dental Hospital (JP)
- Niigata University (JP)
Publication Details
- Journal
- World Journal of Surgical Oncology
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1186/s12957-025-04096-3
- Citations
- 1
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52