Opioid overdose associated with concomitant use of hydrocodone and selective serotonin reuptake inhibitors
In this cohort study, based on data from US healthcare claims databases, initiating citalopram, escitalopram, fluoxetine, or paroxetine while on hydrocodone was associated with an increased risk of opioid overdose compared with sertraline. No substantial risk differences were observed across SSRIs other than sertraline.
Authors
- Sungho Bea (ORCID: https://orcid.org/0000-0003-2622-6553)
- Krista F. Huybrechts (ORCID: https://orcid.org/0000-0001-5805-8430)
- Brian T. Bateman (ORCID: https://orcid.org/0000-0001-5950-8683)
- Robert J. Glynn (ORCID: https://orcid.org/0000-0002-0697-8996)
- Seanna Vine (ORCID: https://orcid.org/0000-0002-6908-4201)
- Katsiaryna Bykov (ORCID: https://orcid.org/0000-0003-3336-5412)
- Shruti Belitkar (ORCID: https://orcid.org/0009-0008-6678-9434)
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Sungkyunkwan University (KR)
- Stanford University (US)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1186/s12916-025-04475-3
- Primary Topic
- Opioid Use Disorder Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Health and Human Services
- Korea Health Industry Development Institute
- Agency for Healthcare Research and Quality