Gingival Traumatic Ulcerative Granuloma With Stromal Eosinophilia (TUGSE) Mimicking Carcinoma

Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is an uncommon benign lesion of the oral mucosa that clinically resembles malignancy, often creating diagnostic concern. We report the case of a 46-year-old woman presenting with a persistent gingival growth in the posterior mandible. Clinical examination revealed a firm erythematous mass with a necrotic white plaque. Histopathology and immunohistochemistry confirmed TUGSE, and surgical excision led to complete healing without recurrence. This case highlights the importance of including TUGSE in the differential diagnosis of chronic oral ulcers and emphasizes early biopsy to avoid misdiagnosis, unnecessary aggressive treatment, and patient distress.

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Publication Details

Journal
Cureus
Published
2025-11-28
DOI
https://doi.org/10.7759/cureus.98006
Primary Topic
Oral and Craniofacial Lesions
Type
article
Field-Weighted Citation Impact
0.00
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article

Gingival Traumatic Ulcerative Granuloma With Stromal Eosinophilia (TUGSE) Mimicking Carcinoma

Shirish Kujur, Shashank Agrawal, Vineeta Gupta, Neha Sahu et al.
Cureus
Oral and Craniofacial Lesions
article

Gingival Traumatic Ulcerative Granuloma With Stromal Eosinophilia (TUGSE) Mimicking Carcinoma

Shirish Kujur, Shashank Agrawal, Vineeta Gupta, Neha Sahu, Sanjum Aasma, Jaishree Borkar
article en

Abstract

Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is an uncommon benign lesion of the oral mucosa that clinically resembles malignancy, often creating diagnostic concern. We report the case of a 46-year-old woman presenting with a persistent gingival growth in the posterior mandible. Clinical examination revealed a firm erythematous mass with a necrotic white plaque. Histopathology and immunohistochemistry confirmed TUGSE, and surgical excision led to complete healing without recurrence. This case highlights the importance of including TUGSE in the differential diagnosis of chronic oral ulcers and emphasizes early biopsy to avoid misdiagnosis, unnecessary aggressive treatment, and patient distress.

CureusVol. 17(11)
Government Dental College and Hospital (IN)
Openalex Percentile: Top 53%
Oral and Craniofacial Lesions
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