Targeting cellular senescence in progenitor cells as a strategy to enhance bone regeneration by cell therapies: a systematic review of pre-clinical investigations
Bone marrow is the most common source of cells for studies of senescence. Cellular senescence characterized by elevated expression of specific markers was consistently shown to be negatively associated with osteogenic capacity and regenerative outcomes. The most common strategies to rejuvenate senescent cells include targeting of senescence markers and oxidative stress. Among these, modulation of p53, p21, and p16 signaling pathways has been highlighted as a potential therapeutic approach for mitigating cell senescence in bone-related conditions.
Authors
- Issei Shinohara (ORCID: https://orcid.org/0000-0002-4122-7119)
- Eshan B. Damle (ORCID: https://orcid.org/0000-0001-7379-7565)
- Stuart B. Goodman (ORCID: https://orcid.org/0000-0002-1919-3717)
- Simon Kwoon‐Ho Chow (ORCID: https://orcid.org/0000-0003-1742-980X)
- Masatoshi Murayama (ORCID: https://orcid.org/0009-0000-1228-482X)
- Qi Gao (ORCID: https://orcid.org/0000-0003-0175-566X)
- Yosuke Susuki (ORCID: https://orcid.org/0009-0002-1458-4361)
- Chao Ma
- Mayu Morita (ORCID: https://orcid.org/0009-0003-8092-0762)
Institutions
- Palo Alto University (US)
- Keio University (JP)
- Stanford Medicine (US)
- Stanford University (US)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1186/s13287-025-04767-8
- Citations
- 1
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Japan Society for the Promotion of Science