Vasculoprotective role of del Nido cardioplegia in open-heart surgery via modulation of E-Selectin, Endocan, and TNF-alpha coronary sinus blood samples
This study uniquely assesses localized endothelial responses via coronary sinus sampling with a multiplex biomarker panel, providing evidence of del Nido cardioplegia's protection. Our findings indicate that del Nido cardioplegia exhibits significant vasculoprotection, as evidenced by modulation of coronary sinus Endocan, E-selectin, and TNF-α. These biomarker changes, together with the absence of adverse differences in major postoperative outcomes, suggest that del Nido cardioplegia provides efficient myocardial and vascular protection in both aortic valve replacement and coronary artery bypass procedures, supporting its safe use in adult elective cardiac surgery.
Authors
- Tamer Cebe (ORCID: https://orcid.org/0000-0003-1069-7131)
- Bülend Ketencі (ORCID: https://orcid.org/0000-0002-8493-0154)
- Mehmet Rum (ORCID: https://orcid.org/0000-0003-4236-0082)
- Fatih Kızılyel (ORCID: https://orcid.org/0000-0001-8299-371X)
- Tamer Kehlіbar (ORCID: https://orcid.org/0000-0002-5274-7654)
- Mehmet Yılmaz (ORCID: https://orcid.org/0000-0002-6243-6876)
- Kübra Bozalı (ORCID: https://orcid.org/0000-0003-2416-0773)
- Şeydanur Turgut (ORCID: https://orcid.org/0000-0003-0898-3083)
Institutions
- Istanbul University-Cerrahpaşa (TR)
- Sağlık Bilimleri Üniversitesi (TR)
- Dr. Siyami Ersek Göğüs Kalp Ve Damar Cerrahisi Eğitim Ve Araştırma Hastanesi (TR)
- Istanbul University (TR)
Publication Details
- Journal
- Journal of Cardiothoracic Surgery
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1186/s13019-025-03751-w
- Citations
- 1
- Primary Topic
- Inflammation biomarkers and pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.80