Brown adipose tissue activation and cardiovascular risk following PD-1 antibody therapy in cancer patients: a retrospective cohort study
PD-1 antibodies enhance BAT activity in cancer patients, and higher BAT activity is associated with reduced arterial stiffness. PET/CT-derived BAT SUVmax may serve as a novel biomarker for cardiovascular risk stratification during PD-1 antibody therapy.
Authors
- Shun Yu (ORCID: https://orcid.org/0000-0002-9073-3886)
- Xiaodan Ou
- Junping Wen
- Bingqian Lin (ORCID: https://orcid.org/0009-0007-2389-1597)
- Gan Chen (ORCID: https://orcid.org/0000-0003-4586-4526)
- Duanyu Lin
- Jinwen Wang (ORCID: https://orcid.org/0000-0002-2545-3319)
Institutions
- Fujian Medical University (CN)
- Fujian Provincial Hospital (CN)
- Fujian Provincial Cancer Hospital (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1186/s40001-025-03463-w
- Primary Topic
- Cardiovascular Disease and Adiposity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- National Science and Technology Major Project