Complement system activation is associated with spinal radiographic progression in axial spondyloarthritis after 2 years of follow-up: findings from the CONSUL RCT
Complement activation marker C3dg, MASP-1 and MASP-3 levels before TNFi therapy predicted new bone formation after 2 years of follow-up among axSpA patients with a high risk of radiographic progression. Furthermore, levels of L-ficolin and C3dg at follow-up were elevated in axSpA patients with new bone formation. Our findings support an association between activation of the complement system and radiographic spinal progression in patients with axSpA.
Authors
- Burkhard Muche (ORCID: https://orcid.org/0000-0003-4104-5080)
- Steffen Thiel (ORCID: https://orcid.org/0000-0002-4817-155X)
- Valeria Ríos Rodríguez (ORCID: https://orcid.org/0000-0001-5612-043X)
- Denis Poddubnyy (ORCID: https://orcid.org/0000-0002-4537-6015)
- Anne Gitte Loft (ORCID: https://orcid.org/0000-0001-6374-841X)
- Mikhail Protopopov (ORCID: https://orcid.org/0000-0003-4840-5069)
- Joachim Listing
- Fabian Proft (ORCID: https://orcid.org/0000-0003-4306-033X)
- Anne Troldborg (ORCID: https://orcid.org/0000-0002-9501-1268)
- Clara Mistegaard (ORCID: https://orcid.org/0000-0002-6359-2192)
- Murat Torğutalp (ORCID: https://orcid.org/0000-0003-4600-9484)
- Joachim Sieper (ORCID: https://orcid.org/0000-0003-0285-9890)
Institutions
- Aarhus University (DK)
- Aarhus University Hospital (DK)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- RMD Open
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1136/rmdopen-2025-006087
- Primary Topic
- Spondyloarthritis Studies and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00