Reprogramming autoimmunity: inducing antigen-specific tolerance via apoptotic mimicry in an experimental model of multiple sclerosis
Our findings indicate that antigen-specific therapy with PS liposomes mimicking apoptotic bodies downregulates the MOG-specific inflammatory immune response and expands Breg and Treg cells, offering a safe, versatile, and easily applicable approach that strongly supports its potential for near-future clinical translation in MS.
Authors
- Marta Vives‐Pi (ORCID: https://orcid.org/0000-0003-3735-0779)
- Herena Eixarch (ORCID: https://orcid.org/0000-0001-7525-9533)
- Xavier Montalbán (ORCID: https://orcid.org/0000-0002-0098-9918)
- Montserrat Mancera-Arteu (ORCID: https://orcid.org/0000-0003-3402-1777)
- Javier Plaza (ORCID: https://orcid.org/0000-0002-8908-1606)
- Bruna Barneda‐Zahonero (ORCID: https://orcid.org/0000-0002-6557-5222)
- Lidia Almenara‐Fuentes (ORCID: https://orcid.org/0000-0002-8518-8078)
- Carmen Espejo (ORCID: https://orcid.org/0000-0001-9949-5901)
- Míriam Salvadó
- Martí Dalmases
- Sílvia Rodríguez-Vidal
- Imane Boutitah-Benyaich
Institutions
- Universitat Autònoma de Barcelona (ES)
- Instituto de Salud Carlos III (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Vall d'Hebron Institut de Recerca (ES)
- Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol (ES)
- Highlight Therapeutics (Spain) (ES)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1186/s12974-025-03618-w
- Citations
- 1
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- European Commission
- Centro para el Desarrollo Tecnológico Industrial
- Generalitat de Catalunya
- Ministerio de Ciencia e Innovación
- Agència de Gestió d'Ajuts Universitaris i de Recerca
- Agencia Estatal de Investigación