Epigenome-wide DNA methylation profiling reveals risk genes for migraine and its subtypes
Our findings provide robust evidence that DNA methylation contributes causally to migraine risk and its subtypes, identify genes of biological and therapeutic relevance, and offer novel insights into the epigenetic mechanisms underlying migraine pathophysiology.
Authors
- Yanmin Peng
- Qiao Jin (ORCID: https://orcid.org/0000-0002-6584-4111)
- Mengge Liu
- Haolin Wang (ORCID: https://orcid.org/0000-0002-1735-9525)
- Xinyu Wang (ORCID: https://orcid.org/0000-0003-0806-4335)
- Wei Wang (ORCID: https://orcid.org/0000-0001-6985-2234)
- Jian Shang
- Dan Zhu (ORCID: https://orcid.org/0000-0003-1186-9505)
- Wenjie Cai (ORCID: https://orcid.org/0000-0002-5352-8779)
- Qi An (ORCID: https://orcid.org/0009-0001-0769-4282)
- Feng Liu (ORCID: https://orcid.org/0009-0002-1358-6736)
- Minghuan Lei
Institutions
- Tianjin Medical University General Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- The Journal of Headache and Pain
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1186/s10194-025-02217-7
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Tianjin Science and Technology Program