Impact of presurgical beta-blockade on surgical outcomes in patients with PPGLs
No previous studies have evaluated the impact of presurgical treatment with beta-blockers on patients with pheochromocytomas and sympathetic paragangliomas (PPGLs) receiving alpha-blockade on surgical outcomes, including intraoperative and postsurgical complications. Considering this context, we analyzed the differences in the rate of intraoperative and postsurgical complications in patients with PPGL based on the use or non-use of preoperative beta-blockade. We found that presurgical beta-blockade was more commonly used in patients with more clinically active tumors. The higher rate of intraoperative arrhythmia in patients pretreated with beta-blockers seems to be related to the more frequent use of phenoxybenzamine in this group and not directly with the use of beta-blocker.
Authors
- Nuria Valdés (ORCID: https://orcid.org/0000-0001-5859-257X)
- Concepción Blanco-Carrera
- María del Castillo Tous
- Monica Sala (ORCID: https://orcid.org/0000-0002-2618-1589)
- Theodora Michalopoulou (ORCID: https://orcid.org/0000-0001-9612-6625)
- Edelmiro Menéndez Torre (ORCID: https://orcid.org/0000-0002-9548-7821)
- Melissa Garcia
- A. Martínez (ORCID: https://orcid.org/0000-0002-1274-4539)
- Rebeca Barahona San Millán (ORCID: https://orcid.org/0000-0002-3049-8407)
- Paz de Miguel Novoa
- Sara Donato (ORCID: https://orcid.org/0000-0001-8704-5292)
- Rocío Revuelta Sánchez-Vera
- Paola Gracia Gimeno
- M. Rodríguez (ORCID: https://orcid.org/0000-0002-0051-0495)
- Marta Araujo‐Castro (ORCID: https://orcid.org/0000-0002-0519-0072)
- C. Mínguez Ojeda (ORCID: https://orcid.org/0000-0002-4188-3298)
- Patricia Pérez Castro
- Patricia Martín Rojas‐Marcos (ORCID: https://orcid.org/0000-0002-3351-2868)
- Cristina Lamas (ORCID: https://orcid.org/0000-0003-4622-9508)
- Mireia Mora (ORCID: https://orcid.org/0000-0002-5887-5016)
- Cristina Robles Lázaro
- Marga González Boillos (ORCID: https://orcid.org/0000-0003-3327-9899)
- Rogelio García-Centeno
- Felicia A. Hanzu (ORCID: https://orcid.org/0000-0002-2399-4023)
- María Calatayud (ORCID: https://orcid.org/0000-0002-6737-7289)
- Pablo Abellán Galiana (ORCID: https://orcid.org/0000-0003-1221-3946)
- Ana Herrero-Ruiz
- Rosario Paniagua Fernández
- Cristina Álvarez-Escolá (ORCID: https://orcid.org/0000-0003-4448-7941)
- Íñigo García Sanz
Institutions
- Hospital Universitario La Paz (ES)
- Universidad Cardenal Herrera CEU (ES)
- University Hospital Complex Of Vigo (ES)
- Hospital General Universitario Gregorio Marañón (ES)
- Hospital Clínico San Carlos (ES)
- BioCruces Health research Institute (ES)
- Hospital Universitario Virgen Macarena (ES)
- Complejo Hospitalario de Salamanca (ES)
- Hospital Universitario 12 De Octubre (ES)
- Hospital Royo Villanova (ES)
- Hospital Universitario Príncipe de Asturias (ES)
- Hospital Universitario Reina Sofía (ES)
- Hospital General Universitari de Castelló (ES)
- Instituto Ramón y Cajal de Investigación Sanitaria (ES)
- Hospital Universitario de La Princesa (ES)
- Hospital Universitario Central de Asturias (ES)
- Hospital de Cruces (ES)
- Hospital Universitario Puerto Real (ES)
- Hospital General Universitario de Albacete (ES)
- Instituto Português de Oncologia de Coimbra Francisco Gentil (PT)
- Hospital Universitari Joan XXIII de Tarragona (ES)
- Consorci Institut D'Investigacions Biomediques August Pi I Sunyer (ES)
- Hospital Universitario Ramón y Cajal (ES)
- Complejo Hospitalario Universitario de Toledo (ES)
- Hospital Universitario de Toledo (ES)
Publication Details
- Journal
- Endocrine Related Cancer
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1530/erc-25-0308
- Primary Topic
- Adrenal and Paraganglionic Tumors
- Type
- article
- Field-Weighted Citation Impact
- 0.00