A serum-free adipose-conditioned medium delays stem cell senescence and maintains tissue homeostasis via IL-6/STAT3 axis suppression
This study identifies a novel xenogeneic-free, paracrine-rich formulation that delays cellular senescence and preserves tissue homeostasis. These findings support its potential as a safe and effective strategy to suppress cellular aging, restore stem cell function, and ameliorate tissue-level aging, offering translational promise for regenerative medicine and anti-aging interventions.
Authors
- Jianhai Bi (ORCID: https://orcid.org/0000-0003-3675-4069)
- Zhenhong Su (ORCID: https://orcid.org/0009-0009-0011-9910)
- Jing Li (ORCID: https://orcid.org/0000-0002-0157-3041)
- Dianwen Song (ORCID: https://orcid.org/0000-0001-6161-2260)
- Lijun Song (ORCID: https://orcid.org/0000-0002-5114-6494)
- Ran Huo (ORCID: https://orcid.org/0000-0002-3513-1073)
Institutions
- Shandong University (CN)
- Shandong Provincial Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1186/s13287-025-04721-8
- Citations
- 2
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 2.33