Histidine ammonia lyase expression characteristics in primary liver cancer: hepatocellular carcinoma and cholangiocarcinoma
Our data evinced the relevance and significance of HAL in the tumorigenesis of HCC and CCA. These findings suggest that HAL and its metabolic derivatives can be developed as a potential prognostic and diagnostic biomarker as well as therapeutics for HCC and CCA.
Authors
- Harlan P. Jones (ORCID: https://orcid.org/0000-0003-3248-0355)
- Pankaj Chaudhary (ORCID: https://orcid.org/0000-0003-0518-4120)
- Hope K. Fiadjoe (ORCID: https://orcid.org/0009-0002-2593-8129)
- In-Woo Park (ORCID: https://orcid.org/0000-0002-3589-1494)
- Tamara Hoteit
Institutions
- University of North Texas (US)
- University of North Texas Health Science Center (US)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1007/s12672-025-04043-4
- Primary Topic
- Chromatin Remodeling and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- Health Science Center, University of North Texas