Cardiac energetics in severe mitral regurgitation: relationship with eccentric hypertrophy, stroke volume, and effects of valve repair
Even with normal LVEF, severe MR is associated with reduced PCr/ATP, CK <i>k</i> <sub>f</sub>, and CK flux. PCr/ATP reduction resolved with MVR. Thus, targeting CK capacity and/or flux may be a therapeutic strategy to prevent/treat systolic failure in MR.
Authors
- Christopher T. Rodgers (ORCID: https://orcid.org/0000-0003-1275-1197)
- Craig A. Lygate (ORCID: https://orcid.org/0000-0001-6079-0284)
- Rana A Sayeed (ORCID: https://orcid.org/0000-0002-2887-1874)
- Moritz Hundertmark (ORCID: https://orcid.org/0000-0002-5475-7987)
- William T. Clarke (ORCID: https://orcid.org/0000-0001-7159-7025)
- John A. Henry (ORCID: https://orcid.org/0000-0002-7650-0963)
- Oliver J. Rider (ORCID: https://orcid.org/0000-0003-1295-7769)
- Mark A. Peterzan (ORCID: https://orcid.org/0000-0002-1793-3128)
- Hannah A. Lake
- W. D. Watson (ORCID: https://orcid.org/0000-0002-2279-6594)
- Jennifer J. Rayner (ORCID: https://orcid.org/0000-0002-3519-5480)
- David Dearlove (ORCID: https://orcid.org/0000-0003-3529-3555)
- Stefan Neubauer (ORCID: https://orcid.org/0000-0001-9017-5645)
- Andrew Lewis (ORCID: https://orcid.org/0000-0002-3714-6711)
- Andrew Apps (ORCID: https://orcid.org/0000-0003-0478-8918)
Institutions
- University of Cambridge (GB)
- John Radcliffe Hospital (GB)
- University of Oxford (GB)
- Wellcome Centre for Integrative Neuroimaging (GB)
- Imaging Center (US)
Publication Details
- Journal
- European Heart Journal - Imaging Methods and Practice
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1093/ehjimp/qyaf146
- Primary Topic
- Cardiac Valve Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- National Institute for Health and Care Research
- British Heart Foundation
- Department of Health and Social Care
- NIHR Oxford Biomedical Research Centre
- NIHR Cambridge Biomedical Research Centre