Postoperative Adjuvant Therapy in Resectable Advanced Oral Squamous Cell Carcinoma With Intermediate Risk Factors
This study demonstrated that perineural invasion is a significant risk factor for recurrence and that lymphatic invasion is a poor prognostic factor in oral cancer. Postoperative adjuvant therapy in patients with perineural or lymphatic invasion-positive disease contributed to reduced recurrence rates and prolonged survival. These findings suggest that the pathological evaluation of perineural and lymphatic invasions is an important indicator in determining the appropriateness of postoperative adjuvant therapy.
Authors
- Koichi Koizumi (ORCID: https://orcid.org/0009-0002-4878-3959)
- Atsuko Hamada (ORCID: https://orcid.org/0000-0001-9892-3097)
- Kota Morishita (ORCID: https://orcid.org/0000-0003-4348-6699)
- Fumitaka Obayashi (ORCID: https://orcid.org/0000-0001-6427-6354)
- Mirai Higaki (ORCID: https://orcid.org/0000-0002-1589-5041)
- Nanako Ito (ORCID: https://orcid.org/0000-0002-1933-7274)
- Sachiko Yamasaki (ORCID: https://orcid.org/0000-0003-0390-7014)
- Souichi Yanamoto (ORCID: https://orcid.org/0000-0003-2372-8347)
Institutions
- Hiroshima University (JP)
Publication Details
- Journal
- Head & Neck
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1002/hed.70106
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00