Targeting ligand PDL1 for cardiotoxicity assessment and cardiac protection in immune-related myocarditis

This study identifies PDL1 as a critical biomarker and therapeutic target for irMyocarditis. PDL1-targeted MRI nanoprobe enables early, noninvasive diagnosis, while AAV9-mediated PDL1 gene therapy offers a promising strategy to mitigate irMyocarditis and restore cardiac function in ICI therapy recipients.

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Publication Details

Journal
Nanomedicine
Published
2025-11-27
DOI
https://doi.org/10.1080/17435889.2025.2595118
Citations
1
Primary Topic
Viral Infections and Immunology Research
Type
article
Field-Weighted Citation Impact
1.39
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article

Targeting ligand PDL1 for cardiotoxicity assessment and cardiac protection in immune-related myocarditis

Haiming Fan, Yingxian Liu, Peijun Liu, Qing Zhong et al.
1 citations
Nanomedicine
Viral Infections and Immunology Research
1.39
article

Targeting ligand PDL1 for cardiotoxicity assessment and cardiac protection in immune-related myocarditis

Haiming Fan, Yingxian Liu, Peijun Liu, Qing Zhong, Jing Guo, Weifang Cao, Xin Zhang, Huan Zhang, Fei Liu, Lulu Liu, Yi Li, Yining Wang, Qun Liu, Xiaoxin Li, Zhuoli Zhang, Guangcheng Liu, Jiaxin Wang
article en
1 citations

Abstract

This study identifies PDL1 as a critical biomarker and therapeutic target for irMyocarditis. PDL1-targeted MRI nanoprobe enables early, noninvasive diagnosis, while AAV9-mediated PDL1 gene therapy offers a promising strategy to mitigate irMyocarditis and restore cardiac function in ICI therapy recipients.

NanomedicineVol. 21(2)
Academy of Medical Sciences (GB), Ministry of Education of the People's Republic of China (CN), Chinese Academy of Sciences (CN), Chinese Academy of Medical Sciences & Peking Union Medical College (CN), University of California, Irvine (US), Peking Union Medical College Hospital (CN), University of California System (US), Northwest University (CN), Zhuhai People's Hospital (CN), Institute of Process Engineering (CN), China Academy of Chinese Medical Sciences (CN)
Openalex Percentile: Top 13%
Viral Infections and Immunology Research
1.39
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