Targeting ligand PDL1 for cardiotoxicity assessment and cardiac protection in immune-related myocarditis
This study identifies PDL1 as a critical biomarker and therapeutic target for irMyocarditis. PDL1-targeted MRI nanoprobe enables early, noninvasive diagnosis, while AAV9-mediated PDL1 gene therapy offers a promising strategy to mitigate irMyocarditis and restore cardiac function in ICI therapy recipients.
Authors
- Haiming Fan (ORCID: https://orcid.org/0000-0002-0091-772X)
- Yingxian Liu (ORCID: https://orcid.org/0000-0003-1155-7130)
- Peijun Liu (ORCID: https://orcid.org/0000-0002-6290-2662)
- Qing Zhong
- Jing Guo (ORCID: https://orcid.org/0000-0003-4709-9733)
- Weifang Cao (ORCID: https://orcid.org/0000-0003-4817-6243)
- Xin Zhang (ORCID: https://orcid.org/0000-0003-4106-0344)
- Huan Zhang (ORCID: https://orcid.org/0000-0002-2289-7707)
- Fei Liu (ORCID: https://orcid.org/0000-0001-8827-4409)
- Lulu Liu (ORCID: https://orcid.org/0000-0001-5227-7923)
- Yi Li (ORCID: https://orcid.org/0000-0002-5189-0627)
- Yining Wang (ORCID: https://orcid.org/0000-0001-6441-2002)
- Qun Liu (ORCID: https://orcid.org/0000-0001-6997-3239)
- Xiaoxin Li (ORCID: https://orcid.org/0000-0002-8645-4331)
- Zhuoli Zhang (ORCID: https://orcid.org/0000-0001-5243-4001)
- Guangcheng Liu (ORCID: https://orcid.org/0009-0004-8138-5930)
- Jiaxin Wang (ORCID: https://orcid.org/0009-0003-1445-2358)
Institutions
- Academy of Medical Sciences (GB)
- Ministry of Education of the People's Republic of China (CN)
- Chinese Academy of Sciences (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- University of California, Irvine (US)
- Peking Union Medical College Hospital (CN)
- University of California System (US)
- Northwest University (CN)
- Zhuhai People's Hospital (CN)
- Institute of Process Engineering (CN)
- China Academy of Chinese Medical Sciences (CN)
Publication Details
- Journal
- Nanomedicine
- Published
- 2025-11-27
- DOI
- https://doi.org/10.1080/17435889.2025.2595118
- Citations
- 1
- Primary Topic
- Viral Infections and Immunology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.39