Incidence and predictors of mortality among TB-HIV co-infected individuals on anti-tuberculosis and anti-retroviral dual therapy in Northwest Ethiopia: A retrospective cohort study
The mortality rate among TB-HIV co-infected patients at Debre Markos Comprehensive Specialized Hospital was high. Being male gender, having a CD4 count below 50 cells/mm³, being ambulatory and bedridden, having low baseline weight, and having low hemoglobin were the important predictors of mortality. To reduce mortality, it is crucial to focus on the early identification and management of high-risk patients, particularly those with low CD4 counts, poor functional status, and low hemoglobin. Strengthening integrated TB and HIV care services is recommended to improve patient survival outcomes.
Authors
- Gashaw Azanaw Amare (ORCID: https://orcid.org/0009-0001-4803-1514)
- Zelalem Dejazmach
- Tebelay Dilnessa (ORCID: https://orcid.org/0000-0002-3713-6783)
- Habtamu Belew (ORCID: https://orcid.org/0009-0009-3955-4370)
- Destaw Kebede
- Bantayehu Addis Tegegne (ORCID: https://orcid.org/0000-0002-6178-8335)
- Bewket Mesganaw (ORCID: https://orcid.org/0000-0001-7384-9003)
- Abebe Fenta (ORCID: https://orcid.org/0000-0002-0775-5639)
- Mekuriaw Belayneh (ORCID: https://orcid.org/0000-0001-7350-8444)
- Fassikaw Kebede (ORCID: https://orcid.org/0000-0002-6117-5272)
- Wubetu Yihunie Belay (ORCID: https://orcid.org/0000-0003-2703-8941)
- Adane Adugna (ORCID: https://orcid.org/0000-0003-1467-2724)
- Desalegn Abebaw (ORCID: https://orcid.org/0009-0007-7787-8961)
- Zigale Hibstu Teffera (ORCID: https://orcid.org/0009-0003-8926-7376)
Institutions
- Woldia University (ET)
- Debre Markos University (ET)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-11-26
- DOI
- https://doi.org/10.1371/journal.pone.0337612
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00