Piperine Targets the FANCL/UBE2T Complex to Inhibit the FA Pathway and Sensitize Bladder Cancer to Cisplatin
Our findings uncover piperine as a natural compound that allosterically inhibits UBE2T activity within the FA pathway, thereby impairing ID2 monoubiquitination and enhancing cisplatin sensitivity in bladder cancer. This study highlights the therapeutic potential of piperine and provides a rationale for targeting the FA repair axis to overcome platinum resistance.
Authors
- Ying Yue (ORCID: https://orcid.org/0009-0007-5605-5739)
- Guanglin Lv (ORCID: https://orcid.org/0009-0008-2635-5412)
- Chen Li (ORCID: https://orcid.org/0009-0007-8601-9296)
- Gui Ma (ORCID: https://orcid.org/0009-0005-2593-4154)
- Bing Lu (ORCID: https://orcid.org/0009-0003-0283-2273)
Institutions
- Soochow University (CN)
- Second Affiliated Hospital of Soochow University (CN)
- Wuxi No.2 People's Hospital (CN)
- The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)
Publication Details
- Journal
- Dose-Response
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1177/15593258251404060
- Primary Topic
- Piperaceae Chemical and Biological Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00