Variable steady inflammation and inflammatory responses in precision-cut lung slices from various IPF lung Regions
Our findings show steady inflammation in normal appearing and transitional areas of IPF lung tissue. These inflammatory markers equally participate in the pro-fibrotic signalling through signal transducers and transcription factors, which might result in dual pro-fibrotic and inflammatory effects during disease progression.
Authors
- Lavinia Neubert (ORCID: https://orcid.org/0000-0003-4130-4185)
- Carlos Machahua (ORCID: https://orcid.org/0000-0003-4964-7393)
- Manuela Funke-Chambour (ORCID: https://orcid.org/0000-0003-3417-5872)
- Patrick Dorn (ORCID: https://orcid.org/0000-0002-7203-3122)
- Thomas M. Marti (ORCID: https://orcid.org/0000-0003-3005-220X)
- Namrata Kewalramani (ORCID: https://orcid.org/0000-0002-8305-1502)
- Christina Petzold-Mügge
Institutions
- University of Bern (CH)
- University Hospital of Bern (CH)
- Medizinische Hochschule Hannover (DE)
- German Center for Lung Research (DE)
Publication Details
- Journal
- Respiratory Research
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1186/s12931-025-03389-1
- Citations
- 1
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- University of Bern