Antioxidative stress effect of chromium‐chelated pea ( <i>Pisum sativum</i> L.) peptides through the Keap1/Nrf2 pathway
Chelated pea peptides could regulate the Keap1/Nrf2/HO-1 antioxidative stress signal pathway, promoting nuclear factor erythroid-2-related factor 2 (Nrf2) nuclear translocation and activating the downstream antioxidant gene heme oxygenase-1 (HO-1) to exert antioxidative stress effects, reducing the oxidative stress levels in the insulin-resistant HepG2 cell model. © 2025 Society of Chemical Industry.
Authors
- Yanqing Zhang (ORCID: https://orcid.org/0000-0001-9030-5876)
- Xianqing Huang (ORCID: https://orcid.org/0000-0001-6649-518X)
- Tiange Li (ORCID: https://orcid.org/0000-0002-5601-9224)
- Peijun Zhao (ORCID: https://orcid.org/0000-0003-1963-4436)
- Yuhong Yuan (ORCID: https://orcid.org/0000-0003-4374-3042)
- Qian Li (ORCID: https://orcid.org/0000-0002-6782-9521)
- Mingwu Qiao
- Lianjun Song (ORCID: https://orcid.org/0000-0002-4463-5687)
Institutions
- Henan University of Technology (CN)
- Zhengzhou University (CN)
- Henan Agricultural University (CN)
Publication Details
- Journal
- Journal of the Science of Food and Agriculture
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1002/jsfa.70293
- Primary Topic
- Protein Hydrolysis and Bioactive Peptides
- Type
- article
- Field-Weighted Citation Impact
- 0.00