Single cell RNA-seq analysis associates Osm signaling in macrophages with osteogenic differentiation during heterotopic ossification
Our findings provide novel insights into understanding the functional impact of macrophages on MPC fate, and we also believe that this may offer new therapeutic opportunities to reduce HO risk by targeting macrophage-driven aberrant progenitor cell differentiation.
Authors
- Xiao‐Hui Yang (ORCID: https://orcid.org/0000-0001-6884-2587)
- Jiangwei Fan
- Jian Wang (ORCID: https://orcid.org/0000-0002-7753-9819)
Institutions
- Xinjiang Medical University (CN)
- Sixth Affiliated Hospital of Xinjiang Medical University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1186/s13018-025-06435-2
- Primary Topic
- Heterotopic Ossification and Related Conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00