Cost-effectiveness of procalcitonin-guided antibiotic duration for hospitalized patients with sepsis

This economic analysis has shown that a PCT-guided protocol to guide the duration of antibiotic treatment could be cost-effective. Where only differences in antibiotic use and PCT testing are assumed, the increased costs per patient are modest which may be seen as worthwhile to safely improve antibiotic stewardship for critically ill adult patients with sepsis.

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Publication Details

Journal
Critical Care
Published
2025-11-28
DOI
https://doi.org/10.1186/s13054-025-05732-w
Primary Topic
Sepsis Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00

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article

Cost-effectiveness of procalcitonin-guided antibiotic duration for hospitalized patients with sepsis

Uzma Manazar, Katherine Richmond, Rachel Rikunenko, Jaimin Patel et al.
Critical Care
Sepsis Diagnosis and Treatment
article

Cost-effectiveness of procalcitonin-guided antibiotic duration for hospitalized patients with sepsis

Uzma Manazar, Katherine Richmond, Rachel Rikunenko, Jaimin Patel, Maite Babio-Galan, Tony Whitehouse, Heather Willis, Bhavin Mistry, Mark De Neef, Christopher Thompson, Andrew J. Donnelly, Charlotte Taylor, Jessica Holden, Louise Walton, Lauren Butler, Ray Cope, Lisa Vipond, Maria Norris, Simon Sinclair, Hiba Omer, Craig Mower, Ian Turner-Bone, Aisling O’Neill, A. S. Duncombe, Helena Baker, Simon Beddows, James J. McNamee, I Clement', Denise Donaldson, Samantha Burn, Benjamin Brown, Yvonne J. Huang, Jackie Todd, Rebecca Jones, Stephen S. Hamilton, Paul M Dark, Gareth McKeeman, Z Auer, Alistair Roy, Rashmi Gupta, Rebecca Gill, Rob Ferguson, Laura Gallagher, Matt Stevenson, Daniel Harvey, J. Crossan, Adam Boulton, Chris Taylor, Katy Edwards, M Kitching, Karen Ellis, Ranjit Lall, Craig Marshall, Paul Alexander, Jessica Watson, Mark Wilkinson, Lucy Barclay, Helen R. Taylor, Katharine Sellers, Lynnette Brammer, Chris Duff, Julia Sampson, J Boxall, Maria Amamio, Kate Briton, Susan Trott, Mohamed Mooradun, J. Jack Lee, Jessica M. Forsyth, Anower Hossain, Justin Roberts, Michael Gillies, Laura Wilding, Ceri Lynch, Leanne Smith, Dominic Kay, Laura Wild, Shondipon Laha, Maria Alexandra Zapata Martinez, J. Harold, Alice Baddeley, Peter McGuigan, Iain James McCullagh, Lisa Bailey, O. Nieto, Chris Goode, Heather Gallagher, Sanal Jose, Laura Reilly, Ian F. Laurenson, Andrew Camplejohn, Sophie Lubbock, Angela Sellick, Sam Foggett, Shatha Abu-Hijleh, Oghenemega Okotete, Ben Storey-Waters, Anthony Mkandhla, Arra Mahiya, Niall Harbison
article en

Abstract

This economic analysis has shown that a PCT-guided protocol to guide the duration of antibiotic treatment could be cost-effective. Where only differences in antibiotic use and PCT testing are assumed, the increased costs per patient are modest which may be seen as worthwhile to safely improve antibiotic stewardship for critically ill adult patients with sepsis.

Critical CareVol. 29(1)
Salford Royal NHS Foundation Trust (GB), University of Warwick (GB), University of Salford (GB), University of Sheffield (GB)
Nottingham University Hospitals NHS Trust, National Institute for Health and Care Research, University College London, University of Nottingham
Openalex Percentile: Top 51%
Sepsis Diagnosis and Treatment
DOIOpen Access PDFOpenAlex
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