RNF186 controls glucose metabolism in metabolic dysfunction-associated fatty liver disease
RNF186 regulates glucose metabolism across multiple tissues in MAFLD, notably by playing a dual role in modulating the transcription and translocation of GLUT4 in skeletal muscle. These findings suggest that targeting the expression of RNF186 could be a potential therapeutic strategy for treating MAFLD and related metabolic disorders.
Authors
- Yuxuan Zhang (ORCID: https://orcid.org/0000-0003-4674-4446)
- Chengmiao Wang
- Dunyong Zhao
- Jiang Du (ORCID: https://orcid.org/0000-0001-8041-1405)
- Juntang Lin (ORCID: https://orcid.org/0000-0002-4203-8117)
- Beilin Kou
- Jingwen Gao (ORCID: https://orcid.org/0000-0002-9772-4608)
- Qizhang Du
- Yan Jiang (ORCID: https://orcid.org/0000-0002-5535-8347)
Institutions
- Army Medical University (CN)
- Southwest Hospital (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1186/s13578-025-01507-6
- Citations
- 1
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- National Natural Science Foundation of China
- Huazhong University of Science and Technology
- Natural Science Foundation of Henan Province