Exploring the impact of endocrine-disrupting chemicals on erectile dysfunction through network toxicology and machine learning
This study systematically characterizes the molecular pathways through which EDCs contribute to ED, with CTNNB1 and HIF1A emerging as central players. The identification of these core targets provides a theoretical foundation for developing targeted interventions against environment-related ED and underscores the importance of mitigating EDC exposure in public health strategies.
Authors
- Qingfu Deng (ORCID: https://orcid.org/0009-0008-4836-9495)
- Xinyao Zhu (ORCID: https://orcid.org/0000-0002-4507-0833)
- Qilong Wu
- Tao Zhou (ORCID: https://orcid.org/0000-0002-9782-7324)
- Juan Wang (ORCID: https://orcid.org/0000-0003-0767-5687)
- Zhiyu Liu (ORCID: https://orcid.org/0000-0002-1678-5960)
- Yuqi Li (ORCID: https://orcid.org/0000-0003-4629-4027)
- Yang Zeng (ORCID: https://orcid.org/0009-0000-4133-4080)
Institutions
- Affiliated Hospital of Southwest Medical University (CN)
- Sichuan Mianyang 404 Hospital (CN)
Publication Details
- Journal
- BMC Pharmacology and Toxicology
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1186/s40360-025-01033-8
- Citations
- 1
- Primary Topic
- Sexual function and dysfunction studies
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Southwest Medical University
- Luzhou Science and Technology Bureau