Computational Investigation Identifies mTOR as a Primary Binding Target of Medicarpin in Cholangiocarcinoma: Insights from Network Pharmacology and Molecular Docking
This study provides systems-level evidence that medicarpin exerts polypharmacological activity against CCA, with mTOR indicated as a possible mechanistic hub. These findings highlight medicarpin's potential as a promising multi-target therapeutic candidate and underscore the value of natural compounds in expanding treatment strategies for cholangiocarcinoma.
Authors
- Sirinya Sitthirak (ORCID: https://orcid.org/0000-0003-2939-1706)
- Yanisa Rattanapan (ORCID: https://orcid.org/0000-0002-5413-6937)
- Aman Tedasen (ORCID: https://orcid.org/0000-0002-1350-1424)
- Watcharin Loilome (ORCID: https://orcid.org/0000-0001-8572-5577)
- Nawanwat Chainuwong Pattaranggoon (ORCID: https://orcid.org/0000-0001-8706-8881)
- Nisana Namwat (ORCID: https://orcid.org/0000-0002-6743-5047)
- Thitinat Duangchan (ORCID: https://orcid.org/0000-0002-7404-6664)
- Krittamate Saisuwan (ORCID: https://orcid.org/0009-0009-0928-2909)
- Hasaya Dokduang (ORCID: https://orcid.org/0009-0004-4765-333X)
Institutions
- Mahasarakham University (TH)
- Khon Kaen University (TH)
- Kyoto University (JP)
- Rangsit University (TH)
- Walailak University (TH)
Publication Details
- Journal
- Life
- Published
- 2025-11-28
- DOI
- https://doi.org/10.3390/life15121828
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Khon Kaen University
- National Research Council of Thailand
- Mahasarakham University
- Walailak University
- Cholangiocarcinoma Research Institute, Khon Kaen University