Association of intercellular adhesion molecule 1 (ICAM-1) (rs5498) genetic polymorphism and dengue in Sabah East Malaysia population
The ICAM-1 rs5498 GG genotype and G allele are significantly associated with increased susceptibility to dengue infection in the Sabahan population, particularly among females. These findings highlight the potential role of ICAM-1 as a genetic biomarker for dengue risk and underscore the importance of considering ethnic and gender differences in genetic epidemiology studies of infectious diseases.
Authors
- Rhanye Mac Guad (ORCID: https://orcid.org/0000-0003-2453-3760)
- Shamala Devi Sekaran (ORCID: https://orcid.org/0000-0002-0478-0425)
- Colin Silvester (ORCID: https://orcid.org/0000-0001-8882-9056)
- Andrew W. Taylor‐Robinson (ORCID: https://orcid.org/0000-0001-7342-8348)
- Nornazirah Azizan (ORCID: https://orcid.org/0000-0002-5831-3734)
- Yin Nwe Aung (ORCID: https://orcid.org/0000-0003-3093-8019)
- Yuan Seng Wu (ORCID: https://orcid.org/0000-0001-5574-8049)
- Maw Shin Sim (ORCID: https://orcid.org/0000-0002-7848-0775)
- Lauren Gee
Institutions
- Universiti of Malaysia Sabah (MY)
- University of Malaya (MY)
- Center for Global Health (US)
- VinUniversity (VN)
- Queen Elizabeth Hospital (MY)
- UCSI University (MY)
- University of Pennsylvania (US)
- Sunway University (MY)
Publication Details
- Journal
- Molecular Biology Reports
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1007/s11033-025-11256-x
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universiti Malaysia Sabah