Association of body roundness index with cardiovascular disease in early Cardiovascular-Kidney-Metabolic syndrome stage 0–3: mediation by the triglyceride-glucose index in a national cohort study
BRI positively linear associated with CVD, especially in early CKM syndrome population. Insulin resistance mediated the BRI-CVD association. The findings highlight BRI's potential for early risk stratification and the multifactorial pathophysiology linking adiposity to CVD.
Authors
- Yuxuan Jiang
- Dongze Zheng (ORCID: https://orcid.org/0009-0009-8340-9568)
- Rou Zhang (ORCID: https://orcid.org/0009-0001-5056-8345)
- Shiyan Jiang (ORCID: https://orcid.org/0000-0002-5279-5920)
- Li Zhang (ORCID: https://orcid.org/0000-0001-7234-9576)
- Bin Wang (ORCID: https://orcid.org/0000-0001-7797-600X)
- Chenlin Li (ORCID: https://orcid.org/0000-0002-9939-5713)
- Sifan Xu (ORCID: https://orcid.org/0000-0002-9186-6656)
- Jiamiao Cai
Institutions
- Wenzhou Medical University (CN)
- Shantou University (CN)
- People 's Hospital of Jilin Province (CN)
- First Affiliated Hospital of Shantou University Medical College (CN)
- Shantou University Medical College (CN)
- Dongyang People's Hospital (CN)
Publication Details
- Journal
- Diabetology & Metabolic Syndrome
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1186/s13098-025-02007-w
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00