Genomic characterization of two distinct Klebsiella pneumoniae strains in a fatal case of relapsed acute myelogenous leukemia: a case report

This case highlights the importance of genome-based diagnostics in identifying mixed-strain infections and uncovering resistance mechanisms that may not be apparent in routine phenotypic assays. The presence of the high-risk clone ST147 and the emerging ST967 lineage in a single host highlights the complexity of managing infections in immunocompromised patients and the urgent need for real-time genomic surveillance to guide antimicrobial stewardship and infection control.