Natural compound triptolide induces caspase-3/GSDME-mediated pyroptosis by promoting ROS accumulation in small cell lung cancer
This study demonstrated the antitumor role of TPL in SCLC and its ability to trigger caspase-3/GSDME-mediated pyroptosis through ROS accumulation, providing new insights into SCLC treatment.
Authors
- Ying Liu (ORCID: https://orcid.org/0000-0002-9528-9366)
- Yaling Long
- Xun Yuan
- Chengyan Wang (ORCID: https://orcid.org/0000-0002-4832-4480)
- Zhaolin Xu (ORCID: https://orcid.org/0000-0002-8553-4081)
- Qian Chu (ORCID: https://orcid.org/0000-0001-8192-7630)
- Yuheng Yan
Institutions
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-11-28
- DOI
- https://doi.org/10.1186/s12935-025-04071-8
- Citations
- 2
- Primary Topic
- Natural Compounds in Disease Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.76
Funders
- National Natural Science Foundation of China