The Effect of Statins on Bleeding in Isolated Coronary Artery Bypass Grafting Statins in CABG

<b>Background:</b> The aim of this study was to investigate the effect of preoperative statin use on postoperative bleeding and related complications in patients undergoing isolated coronary artery bypass grafting (CABG). <b>Methods:</b> Between 2023 and 2025, 627 patients who underwent isolated CABG were evaluated. The patients were divided into two groups: Group A (<i>n</i> = 241, received preoperative statins) and Group B (<i>n</i> = 386, did not receive preoperative statins). All preoperative, intraoperative parameters, and postoperative outcomes were compared. <b>Results:</b> Patient demographics, comorbidities, laboratory parameters, EuroSCORE II, echocardiographic findings, operative data, cross-clamp times, and cardiopulmonary bypass times were similar. Intraoperative and postoperative blood product use were comparable between the groups. Postoperative total bleeding was higher in Group A than in Group B, but no statistical difference was found. The postoperative exploration rate was higher in Group A than in Group B, but no statistically significant difference was found. There were no significant differences between the groups in terms of gastrointestinal bleeding. Postoperative atrial fibrillation (POAF) was significantly lower in Group A than in Group B (21 (8.7%)-74 (19.2%), <i>p</i> < 0.001). Mortality was higher in Group B than in Group A, but no statistically significant difference was found (3 (1.2%)-14 (3.6%), <i>p</i> = 0.07). Intensive care unit stay was longer in Group B than in Group A. A significant negative association was found between statin usage and POAF (<i>p</i> = 0.001, OR = 0.418). <b>Conclusions:</b> We found no statistically significant increase in postoperative bleeding or blood product use with preoperative statin therapy in isolated CABG patients. However, we found that preoperative statin therapy was protective against POAF.