Palladium-catalyzed intermolecular 1,3-dienylation of propargyl esters with alcohols for constructing polysubstituted 1,3-dienes

We have developed a palladium-catalyzed propargylic substitution with alcohols as nucleophiles, wherein monohydric alcohols allow the synthesis of 2-alkoxy-1,3-dienes, while the use of diols allows the formation of 1,4-dioxane derivatives.

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Publication Details

Journal
Organic Chemistry Frontiers
Published
2025-11-28
DOI
https://doi.org/10.1039/d5qo01350j
Primary Topic
Catalytic Alkyne Reactions
Type
article
Field-Weighted Citation Impact
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article

Palladium-catalyzed intermolecular 1,3-dienylation of propargyl esters with alcohols for constructing polysubstituted 1,3-dienes

Shuoshuo Zhang, Ling Jin, Yue Zhang, Xiaolei Huang et al.
Organic Chemistry Frontiers
Catalytic Alkyne Reactions
article

Palladium-catalyzed intermolecular 1,3-dienylation of propargyl esters with alcohols for constructing polysubstituted 1,3-dienes

Shuoshuo Zhang, Ling Jin, Yue Zhang, Xiaolei Huang, Shuizhen Lin, Haohao Jiang
article en

Abstract

We have developed a palladium-catalyzed propargylic substitution with alcohols as nucleophiles, wherein monohydric alcohols allow the synthesis of 2-alkoxy-1,3-dienes, while the use of diols allows the formation of 1,4-dioxane derivatives.

Organic Chemistry FrontiersVol. 13(3)
Zhejiang Normal University (CN)
Openalex Percentile: Top 72%
Catalytic Alkyne Reactions
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