The Association Between Premature Ejaculation and Non-Dipper Blood Pressure: A Cross-Sectional Study

<b>Background/Objectives</b>: Premature ejaculation (PE) is one of the most common sexual problems in men. Autonomic nervous system (ANS), which is an important determinant of circadian changes in blood pressure (BP), also has a mechanism that controls ejaculation. We aimed to investigate the relationship between PE and BP variability. <b>Methods</b>: This cross-sectional study included 80 normotensive patients with PE and 80 healthy volunteers. All the participants underwent 24-h ambulatory BP measurement. Participants were categorized into two groups based on the percentage of nocturnal BP dipping: the dipper BP (DBP), and non-dipper BP (NDBP) groups. <b>Results</b>: The frequency of the NDBP pattern was significantly higher in the PE group compared to the control group (48% vs. 28%, <i>p</i> = 0.009). In the multivariate logistic regression analysis, the NDBP pattern remained significantly associated with PE [odds ratio: 0.399, 95% confidence interval: (0.207-0.770), <i>p</i> = 0.006]. Within the PE group premature ejaculation diagnostic tool (PEDT) scores were significantly higher in individuals with NDBP than individuals with DBP (15.62 ± 2.85 vs. 14.32 ± 2.65, <i>p</i> = 0.038). <b>Conclusions</b>: The frequency of the NDBP pattern was significantly higher in the PE group among normotensive individuals. Additionally, within the PE group, PEDT scores were significantly higher in individuals with the NDBP pattern. A multidisciplinary approach and large-scale prospective studies are necessary to fully elucidate the relationship between PE and the cardiovascular system.